Snip-and-tag DNA sequencing

   May 26, June 2, 2008
A method of fragmenting and mapping DNA molecules provides rapid and inexpensive genome sequencing, which promises to boost medical and biological research.

The technique cuts DNA molecules into 200-base-pair segments, then mixes the segments with a variety of shorter, fluorescently tagged segments. A computer maps the arrangement of fluorescent segments that attach to the longer sample segments to determine the sequence of the original DNA molecules. The process is fast because the tagging and mapping happens across all sample segments at once.

Research paper:
Rapid Genome Sequencing with Short Universal Tiling Probes
Nature Biotechnology, published online May 25, 2008

Researcher's homepage:
Sten Linnarsson

Related stories and briefs:
DNA sequencer on a chip (a biochip for sequencing DNA)

Further info:


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