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Cancer nanoparticles get the picture

  September 15/22, 2008
Bundle a magnetic nanoparticle, a fluorescent quantum dot and a chemotherapy drug in a package one 100th the size of a red blood cell, coat the package with molecules that target cancer cells, and you have a potentially powerful means of tracking and treating cancer.

These hybrid lipid nanoparticles make it possible to observe cancer cells using magnetic resonance imaging and fluorescence imaging. They could be used to allow physicians to administer cancer drugs directly inside cancer cells and track the treatment's progress.

The nanoparticles are the first that carry multiple types of imaging particles and a chemotherapy drug to be tested in laboratory animals, according to the researchers.

Research paper:
Micellar Hybrid Nanoparticles for Simultaneous Magnetofluorescent Imaging and Drug Delivery
Angewandte Chemie International Edition, published online August 11, 2008

Researchers' homepages:
Sailor Research Group
Geoffrey von Maltzahn
Erkki Ruoslahti
Sangeeta N. Bhatia

Related stories and briefs:
Off-the-shelf nanoparticles -- related drug delivery nanoparticles

Further info:
Researchers' video

Back to TRN September 15/22, 2008

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