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Acetaminophen gel delivers drugs

  October 27/November 3, 2008
Convert a common drug into a gel and you have a safe, controlled way to deliver other drugs.

A method of making acetaminophen (the active ingredient of drugs like Tylenol, Datril and Panadol) self-assemble into a hydrogel that encapsulates another drug yields a drug delivery vehicle that slowly releases its cargo in response to temperature and enzyme concentration changes.

The hydrogel breaks down into a fairly benign fatty acid rather than the potentially hazardous polymer fragments of other hydrogels.

Research paper:
Self-assembled Prodrugs: An Enzymatically Triggered Drug-Delivery Platform
Biomaterials, published online October 17, 2008

Researchers' homepages:
Karp Lab
George John's Soft Materials Research Group

Back to TRN October 27/November 3, 2008

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