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Acetaminophen
gel delivers drugs
A method of making acetaminophen (the active ingredient of drugs like Tylenol, Datril and Panadol) self-assemble into a hydrogel that encapsulates another drug yields a drug delivery vehicle that slowly releases its cargo in response to temperature and enzyme concentration changes.
The hydrogel breaks down into a fairly benign fatty acid rather than the potentially hazardous polymer fragments of other hydrogels.
Research paper:
Self-assembled Prodrugs: An Enzymatically Triggered Drug-Delivery Platform
Biomaterials, published online October 17, 2008
Researchers' homepages:
Karp Lab
George John's Soft Materials Research Group
Back to TRN October 27/November 3, 2008
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