Chip controls neural connection

March 10/17, 2004

Researchers from the Max Planck Institute for Biochemistry in Germany and the University of Calgary in Canada have used a silicon chip to coax a pair of nerve cells to communicate.

The two cells communicate with each other using a chemical synapse. When one neuron is electrically excited by a capacitor on the chip it transmits the signal to a second cell. The activity of the second neuron is recorded by a transistor on the chip.

In the brain, chemical synapses enable learning when connections are strengthened by activity. The researchers were able to strengthen the connection between the two neurons by stimulating the first neuron with a series of pulses from a capacitor.

The researchers' device could be used to gain a better understanding of the function of neuronal networks. If the current snail nerve cells can be replaced with rat nerve cells, the chip could be used for pharmaceutical screening, according to the researchers. The prototype chip is also a step toward neurocomputers.

The method could be used for pharmaceutical screening and analysis of neuronal networks in five years. It will take 10 to 20 years before the method can be used to make neurocomputers in the lab. It's not possible to tell when the method could be used to directly connect humans and electronics, according to the researchers. The work appeared in the January 23, 2004 issue of Physical Review Letters.

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